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项目介绍:
肥胖是导致高血压、糖尿病、冠心病等多种慢性疾病发生的主要因素。通过高脂饮食诱导的肥胖模型,更好的模拟了人类疾病的发生发展过程,且模型构建过程简单,稳定性好,并具有易操作、周期较短、可重复性高等有点。
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案例介绍:
Licochalcone A (LA) reduced body weight in high-fat diet (HFD)-induced obese mice. (A) Male mice were fed an HFD (containing 60% fat) for 16 weeks, and administered DMSO, 5 mg/kg licochalcone A (LA5), or 10 mg/kg licochalcone A (LA10) by intraperitoneal injection (I.P.) twice a week from week 4 to 16. (B) Weight gain was measured for 16 weeks. (C) The appearance of the animal and (D) weight gain measured in the last week. (E) Food intake monitored each day.
参考文献:
Protective Effects of Licochalcone A Ameliorates Obesity and Non-Alcoholic Fatty Liver Disease Via Promotion of the Sirt-1/AMPK Pathway in Mice Fed a High-Fat Diet.Cells 2019 05 11;8(5)
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